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I'm curious which battles you guys have given up fighting, at what point you decided they weren't worth fighting, and whether or not the issue still bothers you.
On AD, I don't don't often give up on debate, I typically say what I think and respond to whatever comes from it. However, sometimes I do simply give up. It was moif that said it best for me:
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Or, I will suspend a debate if I am faced with sheer pig headed belligerence that offers nothing but adamant refusal to entertain any notion other than its own. There's just no point banging one's head against a brick wall.
(For the record, this in NOT referring to anyone inparticular so lets keep the drama to a minimum

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In my personal life however, I gave up a significant fight. I gave up on trying to change the GOP and I gave up on trying to get others I know in the GOP to hold those elected accountable. Years back I gave up on the Democrats for the same reason. It just took me a little longer with the GOP.
It does still bother me. It bothers me because there are so many sheep in both parties. People willing to vote for candidates that are simply not good enough because of a irrational fear that to vote for someone else would give the election to the other party and thus the world would end.
It also bothers me because I have, on occasion entertained to possibility of running for office. I was asked to once when I still lived in New Jersey and I declined, but the thought never really died in my mind.
Now, as an Independent, I know my chances are about zero, at least until people realize that the irrational fear I mentioned above is slowing corrupting the process and causing more and more harm to the country.
I'd like to find a way to get more Americans to Vote and get more Voters to Vote for who best represents their beliefs, rather then the lesser of two evils. I'd also like to find a way to get those who are in third parties, to stop using their third party status as a excuse not to consider other ideologies, ideas, or any form of compromise. Perhaps, if hey focused a little more on the election process rather then ideological purity they might have a better shot.
Politics used to be the art of compromise. Now, with crutch phrases like: "for the children", "I voted against it because it didn't go far enough", "they want to destroy ( fill in with: business, the environment, the wealthy, labor, or whatever else)" we have lost compromise in politics. Americans used to be best represented when the congress was evenly divided and the ideologues on both sides where forced to compromise and move to the middle to accomplish anything. Now, they would rather accomplish nothing, than compromise and take a chance on the other guys getting some credit. It's despicable, but it is what national politics has become thanks to all the right wing and left wing pundants, commentators and "journalists" in America.
If we could just get other parties into the game then maybe we could get these ideological mountains to budge a little. Right now, all we have is the choice between one wrong ideological extreme or the other.